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上海信裕生物科技有限公司
SIGMAR1抗体

SIGMAR1抗体

商家询价

产品名称： SIGMAR1抗体

英文名称： SIGMAR1Antibody

产品编号： XY 15168-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 SIGMAR1抗体Applications

In-house applications ELISA, WB, IHC     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
Images
Prev1NextView more validation data
  • 15168-1-AP;mouse kidney tissuemouse kidney tissue were subjected to SDS PAGE followed by western blot with 15168-1-AP(SIGMAR1 antibody) at dilution of 1:500
  • 15168-1-AP;human liver cancerImmunohistochemical of paraffin-embedded human liver cancer using 15168-1-AP(SIGMAR1 antibody) at dilution of 1:50 (under 40x lens)
  • 15168-1-AP;human liver cancerImmunohistochemical of paraffin-embedded human liver cancer using 15168-1-AP(SIGMAR1 antibody) at dilution of 1:50 (under 10x lens)
Positive WB detected in Mouse kidney tissue, mouse brain tissue, mouse colon tissue
Positive IHC detected in Human liver cancer tissue
Recommended dilution WB : 1:200-1:2000
IHC : 1:20-1:200
 SIGMAR1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information SIGMAR1抗体
Immunogen SIGMAR1 fusion protein ag7351 Full name Sigma non-opioid intracellular receptor 1
Calculated molecular
weight		 25 kDa Observed molecular 
weight		 27 kDa
GenBank accession 
number		 BC004899 Gene ID (NCBI) 10280
Gene symbol SIGMAR1 Synonyms FLJ25585, hSigmaR1, OPRS1, SIG 1R, Sigma 1 type opioid receptor, Sigma1 receptor, Sigma1R, SIGMAR1, SR BP, SR BP1, SR31747 binding protein, SRBP
Background

SIGMAR1, also named as OPRS1, SRBP, SIG-1R and AAG8, belongs to the ERG2 family. It is an endoplasmic reticulum chaperone that binds a wide variety of ligands, including neurosteroids, psychostimulants, and dextrobenzomorphans. SIGMAR1 is ubiquitously expressed, and is enriched in motor neurons of the brain and spinal cord. It plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. SIGMAR1 plays a role in several other cell functions including proliferation, survival and death. SDS-PAGE and Western blot analysis showed that SIGMAR1 has an apparent molecular mass of 28 kDa. SIGMAR1 has 5 isoforms with MW 21-27kDa and 12kDa. SIGMAR1抗体

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